Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.

C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses. Fungal recognition by dectin-1 on human dendritic cells engages the CARD9-Bcl10-Malt1 module to activate NF-κB. Here we demonstrate...

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Bibliographic Details
Main Authors: Sonja I Gringhuis, Brigitte A Wevers, Tanja M Kaptein, Toni M M van Capel, Bart Theelen, Teun Boekhout, Esther C de Jong, Teunis B H Geijtenbeek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3024268?pdf=render

Internet

http://europepmc.org/articles/PMC3024268?pdf=render

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