CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice

Abstract Background The chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is the major co-receptor for HIV-1 entry. Individuals with a homozygous CCR5Δ32 mutation have a long lasting and increased resistance to HIV-1 infection. Therefore, CCR5 represents an op...

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Bibliographic Details
Main Authors: Qiaoqiao Xiao, Shuliang Chen, Qiankun Wang, Zhepeng Liu, Shuai Liu, Huan Deng, Wei Hou, Dongcheng Wu, Yong Xiong, Jiafu Li, Deyin Guo
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Retrovirology
Subjects:
CCR5
HIV-1
CRISPR/SaCas9
Primary CD4+ T cells
Human CD34+ hematopoietic stem/progenitor cells
Online Access:http://link.springer.com/article/10.1186/s12977-019-0477-y

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http://link.springer.com/article/10.1186/s12977-019-0477-y

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