Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity of Cryptococcus neoformans

Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity of Cryptococcus neoformans

The high-osmolarity glycerol response (HOG) pathway is pivotal in environmental stress response, differentiation, and virulence of Cryptococcus neoformans, which causes fatal meningoencephalitis. A putative membrane sensor protein, Sho1, has been postulated to regulate HOG pathway, but its regulator...

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Bibliographic Details
Main Authors: Yee-Seul So, Juyeong Jang, Goun Park, Jintao Xu, Michal A. Olszewski, Yong-Sun Bahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
HOG
mucin
C. neoformans
mating
osmotic stress
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02958/full

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