Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies aging (replicative senescence) in yeast cells, however, its contribution to the aging of multicellular orga...

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Bibliographic Details
Main Authors: Kevin L Lu, Jonathan O Nelson, George J Watase, Natalie Warsinger-Pepe, Yukiko M Yamashita
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
rDNA
aging
stem cells
germline
transgenerational inheritance
Online Access:https://elifesciences.org/articles/32421

Internet

https://elifesciences.org/articles/32421

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