The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor (BDNF) is a common genetic variant that can alter therapeutic responses in individuals with Parkinson’s disease...

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Bibliographic Details
Main Authors: Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Parkinson’s disease
Neural grafting
Val66Met
Val68Met
rs6265
BDNF
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304502

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