Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues

by Fredric P. Manfredsson, David C. Bloom, Ronald J. Mandel
Published 2012-11-01

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures.

by Tessa M Grabinski, Andrew Kneynsberg, Fredric P Manfredsson, Nicholas M Kanaan
Published 2015-01-01

Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

by Matthew J. Benskey, Rhyomi C. Sellnow, Ivette M. Sandoval, Ivette M. Sandoval, Caryl E. Sortwell, Caryl E. Sortwell, Jack W. Lipton, Jack W. Lipton, Fredric P. Manfredsson, Fredric P. Manfredsson
Published 2018-02-01

Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates

by Timothy J Collier, D Eugene Redmond, Kathy eSteece-Collier, Jack W Lipton, Fredric P Manfredsson
Published 2016-01-01

A comparison of AAV-vector production methods for gene therapy and preclinical assessment

by Marcus Davidsson, Matilde Negrini, Swantje Hauser, Alexander Svanbergsson, Marcus Lockowandt, Giuseppe Tomasello, Fredric P. Manfredsson, Andreas Heuer
Published 2020-12-01

The Future of GDNF in Parkinson's Disease

by Fredric P. Manfredsson, Nicole K. Polinski, Thyagarajan Subramanian, Nicholas Boulis, Dustin R. Wakeman, Dustin R. Wakeman, Ronald J. Mandel
Published 2020-12-01

Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington’s Disease

by Shreaya Chakroborty, Fredric P. Manfredsson, Alexander M. Dec, Peter W. Campbell, Grace E. Stutzmann, Vahri Beaumont, Anthony R. West
Published 2020-06-01

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

by Zhi-Hao Wang, Jie Xiang, Xia Liu, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Shengxi Wu, Jian-Zhi Wang, Keqiang Ye
Published 2019-07-01

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

by Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop, Fredric P. Manfredsson
Published 2019-01-01

High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.

by D Luke Fischer, Timothy J Collier, Allyson Cole-Strauss, Susan L Wohlgenant, Jack W Lipton, Kathy Steece-Collier, Fredric P Manfredsson, Christopher J Kemp, Caryl E Sortwell
Published 2015-01-01

Impact of age and vector construct on striatal and nigral transgene expression

by Nicole K Polinski, Fredric P Manfredsson, Matthew J Benskey, D Luke Fischer, Christopher J Kemp, Kathy Steece-Collier, Ivette M Sandoval, Katrina L Paumier, Caryl E Sortwell
Published 2016-01-01

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

by Nicholas M. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly, Antonette Bennett, Mavis Agbandje-McKenna, Caryl E. Sortwell, William W. Hauswirth, Shannon E. Boye, Fredric P. Manfredsson
Published 2017-09-01

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

by Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton
Published 2015-01-01

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

by Fredric P. Manfredsson, Kelvin C. Luk, Matthew J. Benskey, Aysegul Gezer, Joanna Garcia, Nathan C. Kuhn, Ivette M. Sandoval, Joseph R. Patterson, Alana O'Mara, Reid Yonkers, Jeffrey H. Kordower
Published 2018-04-01

Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.

by Sara E Gombash, Fredric P Manfredsson, Christopher J Kemp, Nathan C Kuhn, Sheila M Fleming, Ann E Egan, Laura M Grant, Michelle R Ciucci, Jeffrey P MacKeigan, Caryl E Sortwell
Published 2013-01-01

Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Published 2019-11-01

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

by Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Peter F. Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Ye
Published 2018-05-01

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

by Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Published 2021-01-01

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

by Andrea Sturchio, Alok K. Dwivedi, Christina B. Young, Tarja Malm, Luca Marsili, Jennifer S. Sharma, Abhimanyu Mahajan, Emily J. Hill, Samir EL Andaloussi, Kathleen L. Poston, Fredric P. Manfredsson, Lon S. Schneider, Kariem Ezzat, Alberto J. Espay
Published 2021-08-01

Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

by Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Published 2021-08-01