Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey

by Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan, Tessa Grabinski
Published 2021-04-01

Novel Nonphosphorylated Serine 9/21 GSK3β/a Antibodies: Expanding the Toolkit for Studying GSK3 Regulation

by Tessa Grabinski, Nicholas M Kanaan, Nicholas M Kanaan
Published 2016-11-01

EFhd2 Affects Tau Liquid–Liquid Phase Separation

by Irving E. Vega, Irving E. Vega, Irving E. Vega, Andrew Umstead, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan
Published 2019-08-01

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

by Andrew Kneynsberg, Andrew Kneynsberg, Benjamin Combs, Kyle Christensen, Kyle Christensen, Gerardo Morfini, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan
Published 2017-10-01

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies

by Benjamin Combs, Chelsey Hamel, Nicholas M. Kanaan
Published 2016-10-01

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

by Nicholas M. Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Combs
Published 2020-06-01

Tau: A Signaling Hub Protein

by Rebecca L. Mueller, Rebecca L. Mueller, Benjamin Combs, Mohammed M. Alhadidy, Mohammed M. Alhadidy, Scott T. Brady, Scott T. Brady, Gerardo A. Morfini, Gerardo A. Morfini, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan
Published 2021-03-01

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures.

by Tessa M Grabinski, Andrew Kneynsberg, Fredric P Manfredsson, Nicholas M Kanaan
Published 2015-01-01

Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

by Kyle R. Christensen, Thomas G. Beach, Geidy E. Serrano, Nicholas M. Kanaan
Published 2019-02-01

Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization

by Norimichi Shirafuji, Tadanori Hamano, Shu-Hui Yen, Nicholas M. Kanaan, Hirotaka Yoshida, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Masaru Kuriyama, Yasunari Nakamoto
Published 2018-03-01

Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's di...

by Chelsea T. Tiernan, Stephen D. Ginsberg, Bin He, Sarah M. Ward, Angela L. Guillozet-Bongaarts, Nicholas M. Kanaan, Elliott J. Mufson, Scott E. Counts
Published 2018-09-01

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

by Nicholas M. Kanaan, Rhyomi C. Sellnow, Sanford L. Boye, Ben Coberly, Antonette Bennett, Mavis Agbandje-McKenna, Caryl E. Sortwell, William W. Hauswirth, Shannon E. Boye, Fredric P. Manfredsson
Published 2017-09-01

The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.

by Nicholas M Kanaan, Timothy J Collier, Allyson Cole-Strauss, Tessa Grabinski, Zachary R Mattingly, Mary E Winn, Kathy Steece-Collier, Caryl E Sortwell, Fredric P Manfredsson, Jack W Lipton
Published 2015-01-01

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

by Katrina L. Paumier, Kelvin C. Luk, Fredric P. Manfredsson, Nicholas M. Kanaan, Jack W. Lipton, Timothy J. Collier, Kathy Steece-Collier, Christopher J. Kemp, Stephanie Celano, Emily Schulz, Ivette M. Sandoval, Sheila Fleming, Elliott Dirr, Nicole K. Polinski, John Q. Trojanowski, Virginia M. Lee, Caryl E. Sortwell
Published 2015-10-01

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed...

by Joseph R. Patterson, Megan F. Duffy, Christopher J. Kemp, Jacob W. Howe, Timothy J. Collier, Anna C. Stoll, Kathryn M. Miller, Pooja Patel, Nathan Levine, Darren J. Moore, Kelvin C. Luk, Sheila M. Fleming, Nicholas M. Kanaan, Katrina L. Paumier, Omar M.A. El-Agnaf, Caryl E. Sortwell
Published 2019-10-01

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

by Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Published 2018-05-01

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

by Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Published 2018-05-01