SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in Dogs

SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in Dogs

Beta-lactamases, enzymes produced by bacteria to degrade beta-lactam antibiotics, have been harnessed as therapeutics to protect the gut microbiome from damage caused by antibiotics. Proof-of-concept of this approach using SYN-004 (ribaxamase), a beta-lactamase formulated for oral delivery with intr...

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Bibliographic Details
Main Authors: Sheila Connelly, Brian Fanelli, Nur A. Hasan, Rita R. Colwell, Michael Kaleko
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Microorganisms
Subjects:
antibiotic
gut microbiome
beta-lactam
beta-lactamase
beta-lactamase inhibitor
Online Access:https://www.mdpi.com/2076-2607/8/2/152

Internet

https://www.mdpi.com/2076-2607/8/2/152

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