Increased peak detection accuracy in over-dispersed ChIP-seq data with supervised segmentation models

Increased peak detection accuracy in over-dispersed ChIP-seq data with supervised segmentation models

Abstract Background Histone modification constitutes a basic mechanism for the genetic regulation of gene expression. In early 2000s, a powerful technique has emerged that couples chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq). This technique provides a direct survey of the...

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Bibliographic Details
Main Authors: Arnaud Liehrmann, Guillem Rigaill, Toby Dylan Hocking
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Bioinformatics
Subjects:
ChIP-seq
Histone modifications
Over-dispersion
Peak calling
Multiple changepoint detection
Likelihood inference
Online Access:https://doi.org/10.1186/s12859-021-04221-5

Internet

https://doi.org/10.1186/s12859-021-04221-5

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