Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor

In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. In this study, sixteen of benzimidazole-triazolothiadiazine derivatives have been synthes...

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Bibliographic Details
Main Authors: Ulviye Acar Çevik, Betül Kaya Çavuşoğlu, Begüm Nurpelin Sağlık, Derya Osmaniye, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
aromatase
MCF-7
NIH3T3
benzimidazole
triazolothiadiazine
docking
Online Access:https://www.mdpi.com/1420-3049/25/7/1642

Internet

https://www.mdpi.com/1420-3049/25/7/1642

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