Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts

Chronic modulation of AMP-Kinase, Akt and mTOR pathways by ionizing radiation in human lung cancer xenografts

<p><b>Abstract</b></p> <p><b>Introduction</b></p> <p>Earlier, we showed that in cancer cells, AMP-activated kinase (AMPK) participates in a signal transduction pathway involving ATM-AMPK-p53/p21<sup>cip1</sup> which is activated by io...

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Bibliographic Details
Main Authors: Storozhuk Yaryna, Sanli Toran, Hopmans Sarah N, Schultz Carrie, Farrell Tom, Cutz Jean-Claude, Steinberg Gregory R, Wright James, Singh Gurmit, Tsakiridis Theodoros
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Radiation Oncology
Subjects:
Lung cancer
ATM
p53
4-EBP1
p21<sup>cip1</sup>
Online Access:http://www.ro-journal.com/content/7/1/71

Internet

http://www.ro-journal.com/content/7/1/71

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