Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes

Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes

Genetic code expansion has largely relied on two types of the tRNA—aminoacyl-tRNA synthetase pairs. One involves pyrrolysyl-tRNA synthetase (PylRS), which is used to incorporate various lysine derivatives into proteins. The widely used PylRS from Methanosarcinaceae comprises two distinct d...

Full description

Bibliographic Details
Main Authors: Atsushi Yamaguchi, Fumie Iraha, Kazumasa Ohtake, Kensaku Sakamoto
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
genetic code expansion
amber suppression
archaea
benzyloxycarbonyllysine
protein engineering
Online Access:http://www.mdpi.com/1420-3049/23/10/2460

Internet

http://www.mdpi.com/1420-3049/23/10/2460

Similar Items