β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.

The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i knockout (KO) and control mice were tested in...

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Bibliographic Details
Main Authors: Anton Volkov, Stefanie Hagner, Stephan Löser, Safa Alnahas, Hartmann Raifer, Anne Hellhund, Holger Garn, Ulrich Steinhoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3617144?pdf=render