Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism

Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism

Objective: In Parkinson's disease, chronic striatal dopamine depletion results in over-activity and under-activity of the indirect and direct striatal output pathways respectively. In this study, we investigated changes in the function of glutamatergic cortico-striatal synapses that contribute...

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Bibliographic Details
Main Authors: Ruth Warre, Sherri Thiele, Sheena Talwar, Marium Kamal, Tom H. Johnston, Sharon Wang, Doris Lam, Charlotte Lo, Charline S. Khademullah, Gillian Perera, Gabriela Reyes, Xuan Sherry Sun, Jonathan M. Brotchie, Joanne E. Nash
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
Synaptic transmission
Direct pathway
Indirect pathway
BAC transgenic mice
6-OHDA
Electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003475

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http://www.sciencedirect.com/science/article/pii/S0969996110003475

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