Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo

RNA interference (RNAi) is an evolutionarily conserved mechanism for sequence-specific gene silencing. Recent advances in our understanding of RNAi machinery make it possible to reduce protein expression by introducing short hairpin RNA (shRNA) into cells of many systems, however, the efficacy of RN...

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Bibliographic Details
Main Authors: Chih-ming Chen, Shu-Ling Chiu, Wanhua Shen, Hollis Cline
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-07-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.17.001.2009/full