Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arre...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01742-7 |