Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arre...

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Main Authors:	Jennifer S. Fang, Brian G. Coon, Noelle Gillis, Zehua Chen, Jingyao Qiu, Thomas W. Chittenden, Janis M. Burt, Martin A. Schwartz, Karen K. Hirschi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01742-7

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spelling	doaj-db347af2168d4593b642250c5c0ab8aa2021-05-11T07:38:42ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-01742-7Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specificationJennifer S. Fang0Brian G. Coon1Noelle Gillis2Zehua Chen3Jingyao Qiu4Thomas W. Chittenden5Janis M. Burt6Martin A. Schwartz7Karen K. Hirschi8Department of Medicine, Yale University School of MedicineDepartment of Medicine, Yale University School of MedicineDepartment of Medicine, Yale University School of MedicineComputational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXi NextCODE 55 Cambridge ParkwayDepartment of Medicine, Yale University School of MedicineComputational Statistics and Bioinformatics Group, Advanced Artificial Intelligence Research Laboratory, WuXi NextCODE 55 Cambridge ParkwayDepartment of Physiology, College of Medicine, The University of ArizonaDepartment of Medicine, Yale University School of MedicineDepartment of Medicine, Yale University School of MedicineNew vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.https://doi.org/10.1038/s41467-017-01742-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi
spellingShingle	Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification Nature Communications
author_facet	Jennifer S. Fang Brian G. Coon Noelle Gillis Zehua Chen Jingyao Qiu Thomas W. Chittenden Janis M. Burt Martin A. Schwartz Karen K. Hirschi
author_sort	Jennifer S. Fang
title	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_short	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_full	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_fullStr	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_full_unstemmed	Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
title_sort	shear-induced notch-cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	New vessel formation relies on a tightly controlled switch in endothelial biology from proliferating to specializing phenotypes. Here, Fang et al. elucidate the molecular mechanisms of this switch and show that the arterial shear activates a Notch-Cx37-p27 axis promoting endothelial cell cycle arrest and enabling arterial gene expression.
url	https://doi.org/10.1038/s41467-017-01742-7
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Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

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