Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up...

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Main Authors:	Tatsuya Nitabaru, Naoya Kumagai, Masakatsu Shibasaki
Format:	Article
Language:	English
Published:	MDPI AG 2010-03-01
Series:	Molecules
Subjects:	nitro-Mannich ytterbium heterobimetallic asymmetric catalysis amide-based ligand
Online Access:	http://www.mdpi.com/1420-3049/15/3/1280/

id	doaj-db3b99c387b249d3933c5b881fdc02f8
record_format	Article
spelling	doaj-db3b99c387b249d3933c5b881fdc02f82020-11-24T22:03:53ZengMDPI AGMolecules1420-30492010-03-011531280129010.3390/molecules15031280Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic CatalystTatsuya NitabaruNaoya KumagaiMasakatsu ShibasakiA catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines. http://www.mdpi.com/1420-3049/15/3/1280/nitro-Mannichytterbiumheterobimetallicasymmetric catalysisamide-based ligand
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tatsuya Nitabaru Naoya Kumagai Masakatsu Shibasaki
spellingShingle	Tatsuya Nitabaru Naoya Kumagai Masakatsu Shibasaki Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst Molecules nitro-Mannich ytterbium heterobimetallic asymmetric catalysis amide-based ligand
author_facet	Tatsuya Nitabaru Naoya Kumagai Masakatsu Shibasaki
author_sort	Tatsuya Nitabaru
title	Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_short	Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_full	Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_fullStr	Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_full_unstemmed	Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
title_sort	catalytic asymmetric nitro-mannich reactions with a yb/k heterobimetallic catalyst
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2010-03-01
description	A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.
topic	nitro-Mannich ytterbium heterobimetallic asymmetric catalysis amide-based ligand
url	http://www.mdpi.com/1420-3049/15/3/1280/
work_keys_str_mv	AT tatsuyanitabaru catalyticasymmetricnitromannichreactionswithaybkheterobimetalliccatalyst AT naoyakumagai catalyticasymmetricnitromannichreactionswithaybkheterobimetalliccatalyst AT masakatsushibasaki catalyticasymmetricnitromannichreactionswithaybkheterobimetalliccatalyst
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Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

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