Clonal evolution in liver cancer at single-cell and single-variant resolution

Clonal evolution in liver cancer at single-cell and single-variant resolution

Abstract Genetic heterogeneity of tumor is closely related to its clonal evolution, phenotypic diversity and treatment resistance, and such heterogeneity has only been characterized at single-cell sub-chromosomal scale in liver cancer. Here we reconstructed the single-variant resolution clonal evolu...

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Bibliographic Details
Main Authors: Xianbin Su, Linan Zhao, Yi Shi, Rui Zhang, Qi Long, Shihao Bai, Qing Luo, Yingxin Lin, Xin Zou, Shila Ghazanfar, Kun Tao, Guoliang Yang, Lan Wang, Kun-Yan He, Xiaofang Cui, Jian He, Jiao-Xiang Wu, Bo Han, Bin Yan, Biao Deng, Na Wang, Xiaolin Li, Pengyi Yang, Shangwei Hou, Jielin Sun, Jean Y. H. Yang, Jinhong Chen, Ze-Guang Han
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Hematology & Oncology
Subjects:
Hepatocellular carcinoma
Genetic heterogeneity
Somatic mutation
Clonal structure
Tumor evolution
Online Access:https://doi.org/10.1186/s13045-021-01036-y

Internet

https://doi.org/10.1186/s13045-021-01036-y

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