UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells

UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells

Abstract Background H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex. However, it still remains largely uncharacterized how HIRA complex specifi...

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Bibliographic Details
Main Authors: Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, Guohong Li
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Biology
Subjects:
Histone variant H3.3
HIRA complex
UBN1
UBN2
Enhancer
Online Access:http://link.springer.com/article/10.1186/s12915-018-0573-9

Internet

http://link.springer.com/article/10.1186/s12915-018-0573-9

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