Mechanistic Insight into CM18-Tat11 Peptide Membrane-Perturbing Action by Whole-Cell Patch-Clamp Recording

Mechanistic Insight into CM18-Tat11 Peptide Membrane-Perturbing Action by Whole-Cell Patch-Clamp Recording

The membrane-destabilization properties of the recently-introduced endosomolytic CM18-Tat11 hybrid peptide (KWKLFKKIGAVLKVLTTG-YGRKKRRQRRR, residues 1–7 of cecropin-A, 2–12 of melittin, and 47–57 of HIV-1 Tat protein) are investigated in CHO-K1 cells by using the whole-cell configuration of the pat...

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Bibliographic Details
Main Authors: Anna Fasoli, Fabrizio Salomone, Mascia Benedusi, Claudia Boccardi, Giorgio Rispoli, Fabio Beltram, Francesco Cardarelli
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
CPP
AMP
chimera
patch-clamp
toroidal-pore
carpet
Online Access:http://www.mdpi.com/1420-3049/19/7/9228

Internet

http://www.mdpi.com/1420-3049/19/7/9228

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