Guided extraction of genome-scale metabolic models for the integration and analysis of omics data

Omics data can be integrated into a reference model using various model extraction methods (MEMs) to yield context-specific genome-scale metabolic models (GEMs). How to chose the appropriate MEM, thresholding rule and threshold remains a challenge. We integrated mouse transcriptomic data from a Cyp5...

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Bibliographic Details
Main Authors:	Andrew Walakira, Damjana Rozman, Tadeja Režen, Miha Mraz, Miha Moškon
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Computational and Structural Biotechnology Journal
Subjects:	Genome-scale metabolic model Model extraction methods Context-specific metabolic model Omics data integration Subsystem enrichment analysis Model interpretability
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037021002476

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http://www.sciencedirect.com/science/article/pii/S2001037021002476

Guided extraction of genome-scale metabolic models for the integration and analysis of omics data

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