Endothelial Cilia Mediate Low Flow Sensing during Zebrafish Vascular Development

The pattern of blood flow has long been thought to play a significant role in vascular morphogenesis, yet the flow-sensing mechanism that is involved at early embryonic stages, when flow forces are low, remains unclear. It has been proposed that endothelial cells use primary cilia to sense flow, but...

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Bibliographic Details
Main Authors: Jacky G. Goetz, Emily Steed, Rita R. Ferreira, Stéphane Roth, Caroline Ramspacher, Francesco Boselli, Gilles Charvin, Michael Liebling, Claire Wyart, Yannick Schwab, Julien Vermot
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714000667