Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease

Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease

In this study, we examined and characterized disease-specific TCR signatures in cerebrospinal fluid (CSF) of patients with HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP). TCR β libraries using unique molecular identifier–based methodologies were sequenced in paired peripheral bl...

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Bibliographic Details
Main Authors: Satoshi Nozuma, Yoshimi Enose-Akahata, Kory R. Johnson, Maria Chiara Monaco, Nyater Ngouth, Abdel Elkahloun, Joan Ohayon, Jun Zhu, Steven Jacobson
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/jci.insight.144869

Internet

https://doi.org/10.1172/jci.insight.144869

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