IL-Y Aggravates Murine Chronic Graft-Versus-Host Disease by Enhancing T and B Cell Responses

IL-Y Aggravates Murine Chronic Graft-Versus-Host Disease by Enhancing T and B Cell Responses

IL-Y, a synthetic member of IL-12 cytokine family, was found to exert potent immunosuppressive effects by inhibiting the differentiation and activation of Th1 and Th17 cells. However, the role of IL-Y in the development of chronic graft-versus-host disease (cGVHD) remains unknown. Here, using murine...

Full description

Bibliographic Details
Main Authors: Li Wan, Ziqi Jin, Bo Hu, Kangkang Lv, Lei Lei, Yonghao Liu, Yuan Song, Ying Zhu, Huanle Gong, Mimi Xu, Yuanyuan Du, Yang Xu, Haiyan Liu, Depei Wu, Yuejun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
IL-Y
T cell response
B cell response
Tfh cell
Treg cells
chronic graft-versus-host disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.559740/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.559740/full

Similar Items