“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor

“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor

Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as...

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Bibliographic Details
Main Authors: Shiv D. Kale, Brittney N. Mehrkens, Molly M. Stegman, Bridget Kastelberg, Henry Carnes, Rachel J. McNeill, Amy Rizzo, Saikumar V. Karyala, Sheryl Coutermarsh-Ott, Jackie A. Fretz, Ying Sun, Jonathan L. Koff, Govindarajan Rajagopalan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
cytokine release syndrome
superantigens
HLA class II transgenic mice
multiple organ dysfucntion
JAK inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01311/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01311/full

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