In nonhepatic cells, cholesterol 7α-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis

In nonhepatic cells, cholesterol 7α-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis

CHO cells expressing the liver-specific gene product cholesterol-7α-hydroxylase showed a 6-fold increase in the biosynthesis of [14C]cholesterol from [14C]acetate, as well as increased enzymatic activities of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase and squalene synthase. Cells expre...

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Bibliographic Details
Main Authors: Gary M. Spitsen, Svein Dueland, Skaidrite K. Krisans, Casey J. Slattery, Jon H. Miyake, Roger A. Davis
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Journal of Lipid Research
Subjects:
cholesterol
sterol regulation
oxysterols
7α-hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033443X

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http://www.sciencedirect.com/science/article/pii/S002222752033443X

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