Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.

Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.

BACKGROUND: Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative neoplasms (MPNs). The mechanisms of MPL activation remain elusive because of a lack of experimental structures. Modern computational biology techniques were utilized to ex...

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Bibliographic Details
Main Authors: Tai-Sung Lee, Hagop Kantarjian, Wanlong Ma, Chen-Hsiung Yeh, Francis Giles, Maher Albitar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3157383?pdf=render

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http://europepmc.org/articles/PMC3157383?pdf=render

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