Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.

The STING (stimulator of interferon genes) protein can bind cyclic dinucleotides to activate the production of type I interferons and inflammatory cytokines. The cyclic dinucleotides can be bacterial second messengers c-di-GMP and c-di-AMP, 3'5'-3'5' cyclic GMP-AMP (3'3'...

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Bibliographic Details
Main Authors: Guanghui Yi, Volker P Brendel, Chang Shu, Pingwei Li, Satheesh Palanathan, C Cheng Kao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3804601?pdf=render

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http://europepmc.org/articles/PMC3804601?pdf=render

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