Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity

Th17 cells are potent mediators in autoimmune diseases, and RORγt is required for their development. Recent studies have shown that RORγt+ Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt+ Treg cells were also f...

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Bibliographic Details
Main Authors: Byung-Seok Kim, Huiping Lu, Kenji Ichiyama, Xiang Chen, Yi-Bing Zhang, Nipun A. Mistry, Kentaro Tanaka, Young-hee Lee, Roza Nurieva, Li Zhang, Xuexian Yang, Yeonseok Chung, Wei Jin, Seon Hee Chang, Chen Dong
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
Treg
RORγt
Foxp3
autoimmunity
IL-17
Tr17
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312962

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http://www.sciencedirect.com/science/article/pii/S2211124717312962

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