Cyclooxygenase-2 contributes to mutant epidermal growth factor receptor lung tumorigenesis by promoting an immunosuppressive environment

Cyclooxygenase-2 contributes to mutant epidermal growth factor receptor lung tumorigenesis by promoting an immunosuppressive environment

Targeted therapies reduce growth of mutant epidermal growth factor receptor (EGFR) non-small cell lung cancers, but most patients develop drug resistance. This has led to efforts to develop additional therapies. We found abundant activation of the cyclooxygenase-2 (COX-2) axis in a mouse model of mu...

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Bibliographic Details
Main Authors: Mun Kyoung Kim, Aidin Iravani, Matthew K Topham
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Cancer Translational Medicine
Subjects:
cox-2
egfr
immune checkpoint
lung cancer
prostaglandin
Online Access:http://www.cancertm.com/article.asp?issn=2395-3977;year=2020;volume=6;issue=2;spage=40;epage=47;aulast=Kim

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http://www.cancertm.com/article.asp?issn=2395-3977;year=2020;volume=6;issue=2;spage=40;epage=47;aulast=Kim

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