Diazepam causes sedative rather than anxiolytic effects in C57BL/6J mice

Abstract Diazepam has been broadly accepted as an anxiolytic drug and is often used as a positive control in behavioral experiments with mice. However, as opposed to this general assumption, the effect of diazepam on mouse behavior can be considered rather controversial from an evidence point of vie...

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Bibliographic Details
Main Authors: Marina Pádua-Reis, Diana Aline Nôga, Adriano B. L. Tort, Martina Blunder
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88599-5