Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers

Previous studies have shown activation of the immune system and altered immune response in Huntington's disease (HD) gene carriers. Here, we hypothesized that peripheral and central immune responses could be concurrent pathophysiological events and represent a global innate immune response to t...

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Bibliographic Details
Main Authors: Marios Politis, Nayana Lahiri, Flavia Niccolini, Paul Su, Kit Wu, Paolo Giannetti, Rachael I. Scahill, Federico E. Turkheimer, Sarah J. Tabrizi, Paola Piccini
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Microglia
Peripheral inflammation
PET
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300322

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http://www.sciencedirect.com/science/article/pii/S0969996115300322

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