Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host From Viral Infection Through Amplifying Type I Interferon Responses

Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects Host From Viral Infection Through Amplifying Type I Interferon Responses

The metabolite-sensing G protein–coupled receptors (GPCRs) bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. However, the roles of metabolite-sensing GPCRs in viral infection are not well characterized. Here, we identified metabolite-sensi...

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Bibliographic Details
Main Authors: Qingqing Xiong, Hongjun Huang, Ning Wang, Ruoyu Chen, Naiyang Chen, Honghui Han, Qin Wang, Stefan Siwko, Mingyao Liu, Min Qian, Bing Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
TGR5
ISG
metabolite-sensing GPCRs
IFN-I
viral infection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02289/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02289/full

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