A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice

Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) s...

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Bibliographic Details
Main Authors: Susan Thrane, Kara-Lee Aves, Ida E. M Uddbäck, Christoph M. Janitzek, Julianna Han, Yuhe R. Yang, Andrew B. Ward, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Allan R. Thomsen, Jan P. Christensen, Adam F. Sander
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
universal influenza vaccine
HA-stem antigen
capsid-like particles
Virus-like particles
trimer display
IgG2a
Online Access:https://www.mdpi.com/2076-393X/8/3/389

Internet

https://www.mdpi.com/2076-393X/8/3/389

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