A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice
Due to constant antigenic drift and shift, current influenza-A vaccines need to be redesigned and administered annually. A universal flu vaccine (UFV) that provides long-lasting protection against both seasonal and emerging pandemic influenza strains is thus urgently needed. The hemagglutinin (HA) s...
Main Authors: | Susan Thrane, Kara-Lee Aves, Ida E. M Uddbäck, Christoph M. Janitzek, Julianna Han, Yuhe R. Yang, Andrew B. Ward, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Allan R. Thomsen, Jan P. Christensen, Adam F. Sander |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
|
Series: | Vaccines |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-393X/8/3/389 |
Similar Items
-
The Immunogenicity of Capsid-Like Particle Vaccines in Combination with Different Adjuvants Using Different Routes of Administration
by: Christoph M. Janitzek, et al.
Published: (2021-02-01) -
Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines
by: Kara-Lee Aves, et al.
Published: (2020-02-01) -
Virus-Like Particles Produced Using the Brome Mosaic Virus Recombinant Capsid Protein Expressed in a Bacterial System
by: Aleksander Strugała, et al.
Published: (2021-03-01) -
The codon-optimized capsid gene of duck circovirus can be highly expressed in yeast and self-assemble into virus-like particles
by: Cui YANG, et al.
Published: (2017-07-01) -
Head-to-Head Comparison of Modular Vaccines Developed Using Different Capsid Virus-Like Particle Backbones and Antigen Conjugation Systems
by: Laurits Fredsgaard, et al.
Published: (2021-05-01)