Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

Neuroprotective Effects of Herbal Ethanol Extracts from Gynostemma pentaphyllum in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease

6-Hydroxydopamine administration for 28 days (8 μg/2 μL) reduced the number of tyrosine hydroxylase (TH)-immunopositive neurons to 40.2% in the substantia nigra compared to the intact contralateral side. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid and norepinephrine levels were reduc...

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Bibliographic Details
Main Authors: Hyun Sook Choi, Mi Sook Park, Seung Hwan Kim, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Lee
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Molecules
Subjects:
Gynostemma pentaphyllum
6-hydroxydopamine-lesioned rats
tyrosine hydroxylase
dopamine
Parkinson’s disease
Online Access:http://www.mdpi.com/1420-3049/15/4/2814/

Internet

http://www.mdpi.com/1420-3049/15/4/2814/

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