LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection

LFA-1 Mediates Cytotoxicity and Tissue Migration of Specific CD8+ T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection

Integrins mediate the lymphocyte migration into an infected tissue, and these cells are essential for controlling the multiplication of many intracellular parasites such as Trypanosoma cruzi, the causative agent of Chagas disease. Here, we explore LFA-1 and VLA-4 roles in the migration of specific C...

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Bibliographic Details
Main Authors: Camila Pontes Ferreira, Leonardo Moro Cariste, Fernando Dos Santos Virgílio, Barbara Ferri Moraschi, Caroline Brandão Monteiro, Alexandre M. Vieira Machado, Ricardo Tostes Gazzinelli, Oscar Bruna-Romero, Pedro Luiz Menin Ruiz, Daniel Araki Ribeiro, Joseli Lannes-Vieira, Marcela de Freitas Lopes, Mauricio Martins Rodrigues, José Ronnie Carvalho de Vasconcelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
vaccination
Trypanosoma cruzi
migration
integrins
specific CD8+ T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01291/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01291/full

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