The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status

The CD44high Subpopulation of Multifraction Irradiation-Surviving NSCLC Cells Exhibits Partial EMT-Program Activation and DNA Damage Response Depending on Their p53 Status

Ionizing radiation (IR) is used for patients diagnosed with unresectable non-small cell lung cancer (NSCLC). However, radiotherapy remains largely palliative due to the survival of specific cell subpopulations. In the present study, the sublines of NSCLC cells, A549IR (p53wt) and H1299IR (p53null) s...

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Bibliographic Details
Main Authors: Margarita Pustovalova, Lina Alhaddad, Taisia Blokhina, Nadezhda Smetanina, Anna Chigasova, Roman Chuprov-Netochin, Petr Eremin, Ilmira Gilmutdinova, Andreyan N. Osipov, Sergey Leonov
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
non-small cell lung cancer
cancer stem cells
radioresistance
Rad51
p53
epithelial-to-mesenchymal transition
Online Access:https://www.mdpi.com/1422-0067/22/5/2369

Internet

https://www.mdpi.com/1422-0067/22/5/2369

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