Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: Possible implications for GAI pathogenesis
Glutaric (GA) and 3-hydroxyglutaric (OHGA) acids accumulate in glutaric acidemia I (GAI), a neurometabolic disease characterized by acute striatal degeneration and chronic progressive cortical atrophy. To explore the hypothesis that astrocytes are involved in GAI pathogenesis and targets of accumula...
Main Authors: | Silvia Olivera, Anabel Fernandez, Alexandra Latini, Juan Carlos Rosillo, Gabriela Casanova, Moacir Wajner, Patricia Cassina, Luis Barbeito |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2008-12-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108002192 |
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