Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide

Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide

Extracts from the roots of Ononis spinosa L. (restharrow roots) are traditionally used for the treatment of patients with urinary tract infections due to its mild diuretic activity, caused by the inhibition of renal human hyaluronidase-1 by isoflavonoids. Preliminary studies also indicated anti-infl...

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Bibliographic Details
Main Authors: Verena Spiegler, Barbara Gierlikowska, Thorsten Saenger, John N. Addotey, Jandirk Sendker, Joachim Jose, Anna K. Kiss, Andreas Hensel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
Ononis spinosa
restharrow root
inflammation
Toll-like receptor-4
clitorienolactone B
CD11b/CD18
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00889/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00889/full

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