Androgen Deprivation Induces Transcriptional Reprogramming in Prostate Cancer Cells to Develop Stem Cell-Like Characteristics

Enzalutamide, an antiandrogen, is approved for therapy of castration resistant prostate cancer. Clinical applications have shown that approximately 30% of patients acquire resistance after a short period of treatment. However, the molecular mechanisms underlying this resistance is not completely und...

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Bibliographic Details
Main Authors: Shiv Verma, Eswar Shankar, F. Naz Cemre Kalayci, Amrita Mukunda, Malek Alassfar, Vaibhav Singh, E. Ricky Chan, Gregory T. MacLennan, Sanjay Gupta
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/24/9568