Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia.

Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia.

The molecular defects which lead to multistep incidences of human T-cell leukemia have yet to be identified. The DNA-binding protein Helios (known as IKZF2), a member of the Ikaros family of Krüppel-like zinc-finger proteins, functions pivotally in T-cell differentiation and activation. In this stud...

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Bibliographic Details
Main Authors: Shaorong Zhao, Wei Liu, Yinghui Li, Pengjiang Liu, Shufang Li, Daolei Dou, Yue Wang, Rongcun Yang, Rong Xiang, Feifei Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5040427?pdf=render

Internet

http://europepmc.org/articles/PMC5040427?pdf=render

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