The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors
During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has...
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MDPI AG
2009-10-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/1/3/362/ |
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doaj-dbc1cb73c1454c65acc2e2d64958c00d2020-11-24T21:02:01ZengMDPI AGViruses1999-49152009-10-011336238210.3390/v1030362The Natural Selection of Herpesviruses and Virus-Specific NK Cell ReceptorsJoseph C. SunLewis L. LanierDuring the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host receptors allows us to observe a unique molecular example of "survival of the fittest", as virus and immune cells try to out-maneuver one another or for the virus to achieve détente for optimal dissemination in the population. http://www.mdpi.com/1999-4915/1/3/362/NK cellscytomegalovirusevolution |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Joseph C. Sun Lewis L. Lanier |
| spellingShingle |
Joseph C. Sun Lewis L. Lanier The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors Viruses NK cells cytomegalovirus evolution |
| author_facet |
Joseph C. Sun Lewis L. Lanier |
| author_sort |
Joseph C. Sun |
| title |
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
| title_short |
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
| title_full |
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
| title_fullStr |
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
| title_full_unstemmed |
The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors |
| title_sort |
natural selection of herpesviruses and virus-specific nk cell receptors |
| publisher |
MDPI AG |
| series |
Viruses |
| issn |
1999-4915 |
| publishDate |
2009-10-01 |
| description |
During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host receptors allows us to observe a unique molecular example of "survival of the fittest", as virus and immune cells try to out-maneuver one another or for the virus to achieve détente for optimal dissemination in the population. |
| topic |
NK cells cytomegalovirus evolution |
| url |
http://www.mdpi.com/1999-4915/1/3/362/ |
| work_keys_str_mv |
AT josephcsun thenaturalselectionofherpesvirusesandvirusspecificnkcellreceptors AT lewisllanier thenaturalselectionofherpesvirusesandvirusspecificnkcellreceptors AT josephcsun naturalselectionofherpesvirusesandvirusspecificnkcellreceptors AT lewisllanier naturalselectionofherpesvirusesandvirusspecificnkcellreceptors |
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1716776960498073600 |