The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state.

The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state.

The capacity of tumour cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila melanogaster, we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the...

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Bibliographic Details
Main Authors: Nezaket Turkel, Virender K Sahota, Jessica E Bolden, Karen R Goulding, Karen Doggett, Lee F Willoughby, Enrique Blanco, Enrique Martin-Blanco, Montserrat Corominas, Jason Ellul, Toshiro Aigaki, Helena E Richardson, Anthony M Brumby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3715428?pdf=render

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http://europepmc.org/articles/PMC3715428?pdf=render

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