Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C.DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were id...

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Bibliographic Details
Main Authors: Jingkang Shen, Shuyi Yao, Shengli Pan, Lin Chen, Xin Wang, Yongliang Zhang, Tao Meng, Hui Xie, Li Zhang
Format: Article
Language:English
Published: MDPI AG 2012-02-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/17/2/1425/