(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells. In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 also causes...

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Bibliographic Details
Main Authors: Jun-Shiao Chou, Chu-Yu Chen, Ying-Ling Chen, Yi-Hsin Weng, Tu-Hsueh Yeh, Chin-Song Lu, Ya-Ming Chang, Hung-Li Wang
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Neurobiology of Disease
Subjects:
(G2019S) LRRK2
(G2019S) LRRK2 transgenic mouse
SNpc dopaminergic neurons
Evoked dopamine release
Striatal medium spiny neurons
Corticostriatal long-term depression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001119

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http://www.sciencedirect.com/science/article/pii/S0969996114001119

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