Mineral and Matrix Changes in Brtl/+ Teeth Provide Insights into Mineralization Mechanisms

The Brtl/+ mouse is a knock-in model for osteogenesis imperfecta type IV in which a Gly349Cys substitution was introduced into one COL1A1 allele. To gain insight into the changes in dentin structure and mineral composition in these transgenic mice, the objective of this study was to use microcompute...

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Bibliographic Details
Main Authors: Adele L. Boskey, Kostas Verdelis, Lyudmila Spevak, Lyudmila Lukashova, Elia Beniash, Xu Yang, Wayne A. Cabral, Joan C. Marini
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/295812