ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling

The systemic anaphylactic reaction is a life-threatening allergic response initiated by activated mast cells. Sphingolipids are an essential player in the development and attenuation of this response. De novo synthesis of sphingolipids in mammalian cells is inhibited by the family of three ORMDL pro...

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Bibliographic Details
Main Authors: Viktor Bugajev, Ivana Halova, Livia Demkova, Sara Cernohouzova, Petra Vavrova, Michal Mrkacek, Pavol Utekal, Lubica Draberova, Ladislav Kuchar, Björn Schuster, Petr Draber
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
mast cells
passive systemic anaphylaxis
FcϵRI
sphingolipids
ORMDL family
sphingosine-1-phosphate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.591975/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.591975/full

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