Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibilit...

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Bibliographic Details
Main Authors: João Lobo, Ad J. M. Gillis, Carmen Jerónimo, Rui Henrique, Leendert H. J. Looijenga
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
biomarkers
development
epigenetics
germ cell cancer
methylation
microRNAs
testicular cancer
Online Access:http://www.mdpi.com/1422-0067/20/2/258

Internet

http://www.mdpi.com/1422-0067/20/2/258

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